Research Paper
A REVIEW ON PROSTAGLANDINS IN RELATION TO PAINFUL MENSUS AND ITS EVALUATION WITH COX-2 ANTIBODY
Author: Pathak Meenakshi S.N* Prof.Manjari Dwivedi1, Prof. P.L Pakrasi2, Awadhesh Kr. Pandey3
Authors : Pathak Meenakshi S.N* Prof.Manjari Dwivedi1 Prof. P.L Pakrasi2 Awadhesh Kr. Pandey3 *PhD Scholar, Department of Prasuti Tantra, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University.
1 Professor, Department of Prasuti Tantra, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University.
2.Professor, Department of Zoology, Faculty of Science, Banaras Hindu University.
3.PhD Scholar, Department of Shalya Tantra, Faculty of Ayurveda, Institut
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ABSTRACT:
Background
:
Pain is such an alarming symptom that it cannot be neglected at all. In females after puberty, pain is mostly found related to Gynaecological disorders. Amongst them the most commonly met across is painful menses. It restricts a woman from her regular routine and confines her to bed.
Prostaglandins, the causative agent of pain, are found in most tissues and organs. They are produced by almost all nucleated cells. They are
autocrine
and
paracrine
lipid mediators that act upon
platelets
,
endothelium
,
uterine
and
mast cells
.
Prostaglandins play a key role in the generation of the inflammatory response. Their biosynthesis is significantly increased in inflamed tissue and they contribute to the development of the cardinal signs of acute inflammation leading to pain.
Objective:
Excess Prostaglandins PGF2α and PGE2 are released from secretory endometrium of patients during painful menses. These cause spasm of uterine muscles during menses, leading to ischeamic pain. The objective of this paper is to find out the exact relation of Prostaglandins with painful menses and to discuss methods for assessment of Prostaglandin in Endometrium of patients having painful menses,through histology , Immunohistochemistry and Western blot technique.
Keywords
: Prostaglandins, pain, Endometrium, histopathology, COX-2, Immunohistochemistry
